A disruption of the circadian cycleβ€”the metabolic and glandular rhythms that are central to our workaday lifeβ€”seems to be involved in many, if not most, cases of depression; this is why brutal insomnia so often occurs and is most likely why each day’s pattern of distress exhibits fairly predictable alternating periods of intensity and relief. ✨ William Styron (2010). Darkness Visible: A Memoir of Madness, p.16, Open Road Media

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